Practical Experiment Aim To prepare Paracetamol tablets using the wet granulation method and study the process of tablet formulation. Materials Required Active Ingredient: Paracetamol (acetaminophen) powder - 5 g Excipients: Starch (binder and disintegrant) - 1.5 g Lactose (diluent) - 2 g Magnesium stearate (lubricant) - 0.25 g Talc (glidant) - 0.25 g Solvent: Purified water (for binding solution) Equipment Required Mortar and pestle Weighing balance Granulator Drying oven Tablet compression machine Sieves (various mesh sizes) Spatula Measuring cylinder Principle The preparation of Paracetamol tablets involves the wet granulation method, where a binder solution is used to form granules. Granules improve the flow properties of the powder blend and ensure uniformity during tablet compression. The tablets are compressed into a specific size and weight to ensure consistent dosing. Procedure Weighing: Accurately weigh all ingredients using a calibrated weighing balance. Mixing: Mix Paracetamol, starch (10% used as a binder solution), and lactose thoroughly in a mortar until uniform. Granulation: Prepare a starch binder solution by dissolving starch in warm purified water. Slowly add the binder solution to the powder mixture while kneading to form a damp mass. Sieving Wet Mass: Pass the damp mass through a sieve (mesh size 12-16) to form granules. Drying: Dry the granules in an oven at 40–50°C until the moisture content is reduced to an acceptable level (around 3%). Sieving Dry Granules: Pass the dried granules through a sieve (mesh size 20) to ensure uniform size. Blending: Blend the dried granules with magnesium stearate and talc for uniform distribution of the lubricant and glidant. Compression: Compress the final granule blend into tablets using a tablet compression machine. Ensure the tablet weight and hardness are consistent. introduce each requirement thenStep by step follow the procedure